The most children born to one mother is 69.

Feodor Vassilyev was a peasant from Shuya, Russia. His first wife, Mrs. Vassilyev sets the record for most children birthed by a single woman. Ironically She gave birth to a total of “69” children. 😀 However, few other details are known of her life, such as her date of birth or death. She gave birth to 16 pairs of twins, 7 sets of triplets and 4 sets of quadruplets between 1725 and 1765, in a total of 27 births. 67 of the 69 children born are said to have survived infancy.